Article
Bacterial genotoxin colibactin promotes colon tumour growth by inducing a senescence-associated secretory phenotype.
Gut - 1 Dec 2014
Cougnoux Antony, Dalmasso Guillaume, Martinez Ruben, Buc Emmanuel, Delmas Julien, Gibold Lucie, Sauvanet Pierre, Darcha Claude, Déchelotte Pierre, Bonnet Mathilde, Pezet Denis, Wodrich Harald, Darfeuille-Michaud Arlette, Bonnet Richard
Abstract excerpt
BACKGROUND: Escherichia coli strains harbouring the pks island (pks+ E. coli) are often seen in human colorectal tumours and have a carcinogenic effect independent of inflammation in an AOM/IL-10(-/-) (azoxymethane/interleukin) mouse model. OBJECTIVE: To investigate the mechanism sustaining pks+ E. coli-induced carcinogenesis. METHOD: Underlying cell processes were investigated in vitro and in vivo (xenograft...
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