Article
Guanylate cyclase C deficiency causes severe inflammation in a murine model of spontaneous colitis.
PloS one - 1 Jan 2013
Harmel-Laws Eleana, Mann Elizabeth A, Cohen Mitchell B, Steinbrecher Kris A
Abstract excerpt
BACKGROUND: Guanylate Cyclase C (GC-C; Gucy2c) is a transmembrane receptor expressed in intestinal epithelial cells. Activation of GC-C by its secreted ligand guanylin stimulates intestinal fluid secretion. Familial mutations in GC-C cause chronic diarrheal disease or constipation and are associated with intestinal inflammation and infection. Here, we investigated the impact of GC-C activity on mucosal immune...
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