Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Targeted inhibition of miRNA maturation with morpholinos reveals a role for miR-375 in pancreatic islet development.

PLoS biology - 1 Aug 2007

Kloosterman Wigard P, Lagendijk Anne K, Ketting René F, Moulton Jon D, Plasterk Ronald H A

Abstract excerpt

Several vertebrate microRNAs (miRNAs) have been implicated in cellular processes such as muscle differentiation, synapse function, and insulin secretion. In addition, analysis of Dicer null mutants has shown that miRNAs play a role in tissue morphogenesis. Nonetheless, only a few loss-of-function phenotypes for individual miRNAs have been described to date. Here, we introduce a quick and versatile method to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genes, Reporter
Share to In Situ Hybridization

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Islets of Langerhans

Share to Morphogenesis

Share to Oligonucleotides, Antisense

Share to RNA Precursors

Share to Zebrafish

Share to Zebrafish Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 17676975
DOI: 10.1371/journal.pbio.0050203
PMCID: PMC1925136

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeted inhibition of miRNA maturation with morpholinos reveals a role for miR-375 in pancreatic islet development.PMID 17676975Read ↗

MicroRNA Expression Is Required for Pancreatic Islet Cell Genesis in the MouseSemantic proximity Read ↗

The small RNA miR-375 – a pancreatic islet abundant miRNA with multiple roles in endocrine beta cell functionSemantic proximity Read ↗

MicroRNAs regulate brain morphogenesis in zebrafish.Semantic proximity Read ↗

Antisense miR-7 Impairs Insulin Expression in Developing Pancreas and in Cultured Pancreatic BudsSemantic proximity Read ↗

The Promoter of the pri-miR-375 Gene Directs Expression Selectively to the Endocrine PancreasSemantic proximity Read ↗

The role of microRNAs in islet β‐cell developmentSemantic proximity Read ↗

The microRNA-producing enzyme Dicer1 is essential for zebrafish development.Semantic proximity Read ↗

Mice lacking microRNAs in Pax8-expressing cells develop hypothyroidism and end-stage renal failure.Semantic proximity Read ↗

Out with the old, in with the new: reassessing morpholino knockdowns in light of genome editing technology.Semantic proximity Read ↗

Wnt5 signaling in vertebrate pancreas developmentSemantic proximity Read ↗

A role for noncanonical microRNAs in the mammalian brain revealed by phenotypic differences in Dgcr8 versus Dicer1 knockouts and small RNA sequencing.Semantic proximity Read ↗

MicroRNA function is globally suppressed in mouse oocytes and early embryos.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.