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Article

MicroRNAs regulate brain morphogenesis in zebrafish.

Science (New York, N.Y.) - 6 May 2005

Giraldez Antonio J, Cinalli Ryan M, Glasner Margaret E, Enright Anton J, Thomson J Michael, Baskerville Scott, Hammond Scott M, Bartel David P, Schier Alexander F

Abstract excerpt

MicroRNAs (miRNAs) are small RNAs that regulate gene expression posttranscriptionally. To block all miRNA formation in zebrafish, we generated maternal-zygotic dicer (MZdicer) mutants that disrupt the Dicer ribonuclease III and double-stranded RNA-binding domains. Mutant embryos do not process precursor miRNAs into mature miRNAs, but injection of preprocessed miRNAs restores gene silencing, indicating that the...

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PMID: 15774722
DOI: 10.1126/science.1109020

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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