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Article

The microRNA-producing enzyme Dicer1 is essential for zebrafish development.

Nature genetics - 1 Nov 2003

Wienholds Erno, Koudijs Marco J, van Eeden Freek J M, Cuppen Edwin, Plasterk Ronald H A

Abstract excerpt

MicroRNAs (miRNAs) are produced by the Dicer1 enzyme; the role of Dicer1 in vertebrate development is unknown. Here we report target-selected inactivation of the dicer1 gene in zebrafish. We observed an initial build-up of miRNA levels, produced by maternal Dicer1, in homozygous dicer1 mutants, b...

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PMID: 14528306
DOI: 10.1038/ng1251

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14528306-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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