Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MicroRNA function is globally suppressed in mouse oocytes and early embryos.

Current biology : CB - 9 Feb 2010

Suh Nayoung, Baehner Lauren, Moltzahn Felix, Melton Collin, Shenoy Archana, Chen Jing, Blelloch Robert

Abstract excerpt

Dicer, which is required for the processing of both microRNAs (miRNAs) and small interfering RNAs (siRNAs), is essential for oocyte maturation [1, 2]. Oocytes express both miRNAs and endogenous siRNAs (endo-siRNAs) [3, 4]. To determine whether the abnormalities in Dicer knockout oocytes during meiotic maturation are secondary to the loss of endo-siRNAs and/or miRNAs, we deleted Dgcr8, which encodes an RNA-binding...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blastocyst
Share to DEAD-box RNA Helicases
Share to Endoribonucleases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to MicroRNAs

Share to Oocytes

Share to Ribonuclease III

Share to RNA-Binding Proteins

Share to RNA Processing, Post-Transcriptional

Source

Open in PubMed Open full text

Identifiers

PMID: 20116247
DOI: 10.1016/j.cub.2009.12.044
PMCID: PMC2872512

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MicroRNA function is globally suppressed in mouse oocytes and early embryos.PMID 20116247Read ↗

Mouse ES cells express endogenous shRNAs, siRNAs, and other Microprocessor-independent, Dicer-dependent small RNAs.Semantic proximity Read ↗

Deletion of Dicer in Somatic Cells of the Female Reproductive Tract Causes SterilitySemantic proximity Read ↗

MicroRNA in the ovary and female reproductive tract1Semantic proximity Read ↗

DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal.Semantic proximity Read ↗

Dicer1 Is Required for Differentiation of the Mouse Male Germline1Semantic proximity Read ↗

A role for noncanonical microRNAs in the mammalian brain revealed by phenotypic differences in Dgcr8 versus Dicer1 knockouts and small RNA sequencing.Semantic proximity Read ↗

Dicer Is Required for Haploid Male Germ Cell Differentiation in MiceSemantic proximity Read ↗

DGCR8-dependent microRNA biogenesis is essential for skin development.Semantic proximity Read ↗

Impaired microRNA processing causes corpus luteum insufficiency and infertility in mice.Semantic proximity Read ↗

Maternal loss-of-function of Nlrp2 results in failure of epigenetic reprogramming in mouse oocytesSemantic proximity Read ↗

MicroRNAs regulate brain morphogenesis in zebrafish.Semantic proximity Read ↗

The microRNA-producing enzyme Dicer1 is essential for zebrafish development.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.