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Article

The Promoter of the pri-miR-375 Gene Directs Expression Selectively to the Endocrine Pancreas

2 Apr 2009

Abstract excerpt

microRNAs (miRNAs) are known to play an essential role in controlling a broad range of biological processes including animal development. Accordingly, many miRNAs are expressed preferentially in one or a small number of cell types. Yet the mechanisms responsible for this selectivity are not well understood. The aim of this study was to elucidate the molecular basis of cell-specific expression of the pri-miR-375...

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PMID: 19343226
DOI: 10.1371/journal.pone.0005033

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