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Article

An intermediary role of proHB-EGF shedding in growth factor-induced c-Myc gene expression.

Journal of cellular physiology - 1 Feb 2008

Nanba Daisuke, Inoue Hirofumi, Shigemi Yuka, Shirakata Yuji, Hashimoto Koji, Higashiyama Shigeki

Abstract excerpt

Activation of growth factor receptors by ligand binding leads to an increased expression of c-Myc, a transcriptional regulator for cell proliferation. The activation of transcriptional factors via the activated receptors is thought to be the main role of c-Myc gene expression. We demonstrate here that epidermal growth factor receptor (EGFR)- and fibroblast growth factor receptor (FGFR)-mediated c-Myc induction...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17674363
DOI: 10.1002/jcp.21233

Genes

EGF
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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