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Article

c-myc Is a Downstream Target of the Smad Pathway

1 Jan 2002

Abstract excerpt

c-Myc is one of the most potent regulators of cell cycle progression in higher eukaryotes. Down-regulation of c-Myc is a critical event for growth inhibition induced by transforming growth factor-beta (TGF-beta) and is frequently impaired in cancer cells. We determined a Smad-responsive element in the c-myc promoter. This element is a complex of the TGF-beta1 inhibitory element (TIE) originally identified in the...

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PMID: 11689553
DOI: 10.1074/jbc.m104170200

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