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Article

Secreted and O-GlcNAcylated MIF binds to the human EGF receptor and inhibits its activation.

Nature cell biology - 1 Oct 2015

Zheng Yanhua, Li Xinjian, Qian Xu, Wang Yugang, Lee Jong-Ho, Xia Yan, Hawke David H, Zhang Gang, Lyu Jianxin, Lu Zhimin

Abstract excerpt

Activation of epidermal growth factor receptor (EGFR), which occurs in many types of tumour, promotes tumour progression. However, no extracellular antagonist of human EGFR has been identified. We found that human macrophage migration inhibitory factor (MIF) is O-GlcNAcylated at Ser 112/Thr 113 at its carboxy terminus. The naturally secreted and O-GlcNAcylated MIF binds to EGFR, thereby inhibiting the binding of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26280537
DOI: 10.1038/ncb3222
PMCID: PMC4785887

Genes

EGFR
MIF
EGF
MMP13

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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