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Article

The heparin-binding domain of HB-EGF mediates localization to sites of cell-cell contact and prevents HB-EGF proteolytic release.

Journal of cell science - 1 Jul 2010

Prince Robin N, Schreiter Eric R, Zou Peng, Wiley H Steven, Ting Alice Y, Lee Richard T, Lauffenburger Douglas A

Abstract excerpt

Heparin-binding EGF-like growth factor (HB-EGF) is a ligand for EGF receptor (EGFR) and possesses the ability to signal in juxtacrine, autocrine and/or paracrine mode, with these alternatives being governed by the degree of proteolytic release of the ligand. Although the spatial range of diffusion of released HB-EGF is restricted by binding heparan-sulfate proteoglycans (HSPGs) in the extracellular matrix and/or...

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Source

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Identifiers

PMID: 20530570
DOI: 10.1242/jcs.058321
PMCID: PMC2886746

Genes

EGF
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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