Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ectodomain shedding of HB-EGF: a potential target for cancer therapy.

Journal of biochemistry - 1 Jan 2012

Miyazono Kohei

Abstract excerpt

Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is synthesized as a membrane-anchored protein, known as proHB-EGF. ProHB-EGF is cleaved by metalloproteases through a process referred to as 'ectodomain shedding', resulting in the formation of soluble HB-EGF. Both proHB-EGF and soluble HB-EGF are biologically active; the former acts on neighbouring cells through juxtacrine signalling, whereas...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies, Monoclonal
Share to Antibody Specificity
Share to Cell Proliferation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epidermal Growth Factor

Share to Heparin-binding EGF-like Growth Factor

Share to Intercellular Signaling Peptides and Proteins

Share to Metalloproteases

Share to Protein Precursors

Source

Identifiers

PMID: 21976708
DOI: 10.1093/jb/mvr120

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ectodomain shedding of HB-EGF: a potential target for cancer therapy.PMID 21976708Read ↗

Heparin-binding epidermal growth factor-like growth factor as a novel targeting molecule for cancer therapy.Semantic proximity Read ↗

Identification of diphtheria toxin R domain mutants with enhanced inhibitory activity against HB-EGF.Semantic proximity Read ↗

Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a mediator of multiple physiological and pathological pathways.Semantic proximity Read ↗

HB-EGF is a potent inducer of tumor growth and angiogenesis.Semantic proximity Read ↗

Suppression of the biological activities of the epidermal growth factor (EGF)-like domain by the heparin-binding domain of heparin-binding EGF-like Growth Factor.Semantic proximity Read ↗

The heparin-binding domain of HB-EGF mediates localization to sites of cell-cell contact and prevents HB-EGF proteolytic release.Semantic proximity Read ↗

Mice with defects in HB-EGF ectodomain shedding show severe developmental abnormalities.Semantic proximity Read ↗

Discovery of HB-EGF binding peptides and their functional characterization in ovarian cancer cell linesSemantic proximity Read ↗

Significance of the association between heparin‐binding epidermal growth factor‐like growth factor and CD9 in human gastric cancerSemantic proximity Read ↗

An intermediary role of proHB-EGF shedding in growth factor-induced c-Myc gene expression.Semantic proximity Read ↗

Cytoplasmic domain phosphorylation of heparin-binding EGF-like growth factor.Semantic proximity Read ↗

Juxtacrine activation of epidermal growth factor (EGF) receptor by membrane-anchored heparin-binding EGF-like growth factor protects epithelial cells from anoikis while maintaining an epithelial phenotype.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.