Article
HB-EGF is a potent inducer of tumor growth and angiogenesis.
Cancer research - 1 Aug 2004
Ongusaha Pat P, Kwak Jennifer C, Zwible Andrew J, Macip Salvador, Higashiyama Shigeki, Taniguchi Naoyuki, Fang Li, Lee Sam W
Abstract excerpt
Heparin-binding epidermal growth factor-like growth factor (HB-EGF) has been shown to stimulate the growth of a variety of cells in an autocrine or paracrine manner. Although HB-EGF is widely expressed in tumors compared with normal tissue, its contribution to tumorigenicity is unknown. HB-EGF can be produced as a membrane-anchored form (pro-HB-EGF) and later processed to a soluble form (s-HB-EGF), although a...
Topics
- Animals
- Blotting, Northern
- Cell Division
- Cell Membrane
- Cell Movement
- Cell Transformation, Neoplastic
- Colony-Forming Units Assay
- Cyclin D1
- Cytosol
- Epidermal Growth Factor
- Gene Expression Regulation
- Heparin-binding EGF-like Growth Factor
- Humans