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Article

HB-EGF is a potent inducer of tumor growth and angiogenesis.

Cancer research - 1 Aug 2004

Ongusaha Pat P, Kwak Jennifer C, Zwible Andrew J, Macip Salvador, Higashiyama Shigeki, Taniguchi Naoyuki, Fang Li, Lee Sam W

Abstract excerpt

Heparin-binding epidermal growth factor-like growth factor (HB-EGF) has been shown to stimulate the growth of a variety of cells in an autocrine or paracrine manner. Although HB-EGF is widely expressed in tumors compared with normal tissue, its contribution to tumorigenicity is unknown. HB-EGF can be produced as a membrane-anchored form (pro-HB-EGF) and later processed to a soluble form (s-HB-EGF), although a...

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Identifiers

PMID: 15289334
DOI: 10.1158/0008-5472.CAN-04-0925

Genes

EGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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