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Article

Mice with defects in HB-EGF ectodomain shedding show severe developmental abnormalities.

The Journal of cell biology - 10 Nov 2003

Yamazaki Satoru, Iwamoto Ryo, Saeki Kazuko, Asakura Masanori, Takashima Seiji, Yamazaki Ayano, Kimura Rina, Mizushima Hiroto, Moribe Hiroki, Higashiyama Shigeki, Endoh Masayuki, Kaneda Yasufumi, Takagi Satoshi, Itami Satoshi, Takeda Naoki, Yamada Gen, Mekada Eisuke

Abstract excerpt

Heparin-binding EGF-like growth factor (HB-EGF) is first synthesized as a membrane-anchored form (proHB-EGF), and its soluble form (sHB-EGF) is released by ectodomain shedding from proHB-EGF. To examine the significance of proHB-EGF processing in vivo, we generated mutant mice by targeted gene replacement, expressing either an uncleavable form (HBuc) or a transmembrane domain-truncated form (HBdeltatm) of the...

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Share to Cell Surface Extensions
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heart Defects, Congenital

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Source

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Identifiers

PMID: 14597776
DOI: 10.1083/jcb.200307035
PMCID: PMC2173637

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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