Article
Association of the colorectal cancer and MDR1 gene polymorphism in an Iranian population.
Molecular biology reports - 1 Jun 2011
Khedri Azam, Nejat-Shokouhi Amireh, Salek Roham, Esmaeili Habibollah, Mokhtarifar Ali, Entezari Heravi Reza, Tatari Farnoosh, Behravan Javad, Miladpour Behnoosh, Omidvar Tehrani Shahireh
Abstract excerpt
The human multidrug resistance (MDR1) gene product P-glycoprotein is highly expressed in intestinal epithelial cells, where it constitutes a barrier against xenobiotics, bacterial toxins, drugs and other biologically active compounds, possibly carcinogens. In this study, an association of MDR1 gene polymorphism and the occurrence of colorectal cancer were evaluated. In this case-control-designed 118 unrelated...
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