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Article

Association between the C3435T single-nucleotide polymorphism of multidrug resistance 1 gene and risk of gastric cancer.

Molecular medicine reports - 1 Aug 2012

Oliveira Juliana, Felipe Aledson V, Chang Paula Y J, Pimenta Celia A M, Silva Tiago D, Massud João, Forones Nora M

Abstract excerpt

The multidrug resistance 1 (MDR1) gene encodes P-glycoprotein, which confers resistance to antineoplastic drugs, but also affects the kinetic disposition of certain drugs and carcinogens. The C3435T polymorphism of the MDR1 gene may influence the transport and excretion of carcinogens, increasing the risk of cancer. The aim of this study was to evaluate the association between this polymorphism and the risk of...

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Share to ATP Binding Cassette Transporter, Subfamily B
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22641402
DOI: 10.3892/mmr.2012.926

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Association between the C3435T single-nucleotide polymorphism of multidrug resistance 1 gene and risk of gastric cancer.PMID 22641402Read ↗

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