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Article

A whole genome association study of neuroticism using DNA pooling.

Molecular psychiatry - 1 Mar 2008

Shifman S, Bhomra A, Smiley S, Wray N R, James M R, Martin N G, Hettema J M, An S S, Neale M C, van den Oord E J C G, Kendler K S, Chen X, Boomsma D I, Middeldorp C M, Hottenga J J, Slagboom P E, Flint J

Abstract excerpt

We describe a multistage approach to identify single nucleotide polymorphisms (SNPs) associated with neuroticism, a personality trait that shares genetic determinants with major depression and anxiety disorders. Whole genome association with 452 574 SNPs was performed on DNA pools from approximately 2000 individuals selected on extremes of neuroticism scores from a cohort of 88 142 people from southwest England....

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Identifiers

PMID: 17667963
DOI: 10.1038/sj.mp.4002048
PMCID: PMC4004964

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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