Article
Genome-wide association uncovers shared genetic effects among personality traits and mood states.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Sept 2012
Luciano Michelle, Huffman Jennifer E, Arias-Vásquez Alejandro, Vinkhuyzen Anna A E, Middeldorp Christel M, Giegling Ina, Payton Antony, Davies Gail, Zgaga Lina, Janzing Joost, Ke Xiayi, Galesloot Tessel, Hartmann Annette M, Ollier William, Tenesa Albert, Hayward Caroline, Verhagen Maaike, Montgomery Grant W, Hottenga Jouke-Jan, Konte Bettina, Starr John M, Vitart Veronique, Vos Pieter E, Madden Pamela A F, Willemsen Gonneke, Konnerth Heike, Horan Michael A, Porteous David J, Campbell Harry, Vermeulen Sita H, Heath Andrew C, Wright Alan, Polasek Ozren, Kovacevic Sanja B, Hastie Nicholas D, Franke Barbara, Boomsma Dorret I, Martin Nicholas G, Rujescu Dan, Wilson James F, Buitelaar Jan, Pendleton Neil, Rudan Igor, Deary Ian J
Abstract excerpt
Measures of personality and psychological distress are correlated and exhibit genetic covariance. We conducted univariate genome-wide SNP (~2.5 million) and gene-based association analyses of these traits and examined the overlap in results across traits, including a prediction analysis of mood states using genetic polygenic scores for personality. Measures of neuroticism, extraversion, and symptoms of anxiety,...
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