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Article

Modeling prior information of common genetic variants improves gene discovery for neuroticism.

Human molecular genetics - 15 Nov 2017

Lo Min-Tzu, Wang Yunpeng, Kauppi Karolina, Sanyal Nilotpal, Fan Chun-Chieh, Smeland Olav B, Schork Andrew, Holland Dominic, Hinds David A, Tung Joyce Y, Andreassen Ole A, Dale Anders M, Chen Chi-Hua

Abstract excerpt

Neuroticism reflects emotional instability, and is related to various mental and physical health issues. However, the majority of genetic variants associated with neuroticism remain unclear. Inconsistent genetic variants identified by different genome-wide association studies (GWAS) may be attributable to low statistical power. We proposed a novel framework to improve the power for gene discovery by incorporating...

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Share to Genetic Variation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Linkage Disequilibrium

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Share to Polymorphism, Single Nucleotide

Share to Sequence Analysis, DNA

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Identifiers

PMID: 28973307
DOI: 10.1093/hmg/ddx340
PMCID: PMC5886256

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CADM2

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