Article
CYP3A5*3 and CYP3A4*1B allele distribution and genotype combinations: differences between Spaniards and Central Americans.
Therapeutic drug monitoring - 1 Aug 2007
Sinues Blanca, Vicente Jorge, Fanlo Ana, Vasquez Patricia, Medina Juan Carlos, Mayayo Esteban, Conde Blanca, Arenaz Izaskun, Martinez-Jarreta Begoña
Abstract excerpt
The aim of this study was to detect genotypic differences between three populations of healthy volunteers from Northern Spain (204 subjects), Nicaragua (120 subjects), and El Salvador (112 subjects) regarding CYP3A4*1B and CYP3A5*3 polymorphisms. No significant differences were found by comparing allelic frequencies between the two Central American populations. The CYP3A5*3 allele frequency was significantly...
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