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Article

Impaired Expression of Perforin and Granulysin in CD8+T Cells at the Site of Infection in Human Chronic Pulmonary Tuberculosis

31 Jul 2007

Abstract excerpt

Protective immunity in tuberculosis is dependent on the coordinated release of cytolytic effector molecules from effector T cells and the subsequent granule-associated killing of infected target cells. In this study, we investigated the expression of cytolytic (perforin and granzyme A) and antimicrobial (granulysin) molecules at the single-cell level in cryopreserved lung tissue from patients with chronic,...

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Identifiers

PMID: 17664265
DOI: 10.1128/iai.00624-07

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