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Understanding the development of tuberculous granulomas: insights into host protection and pathogenesis, a review in humans and animals

9 Dec 2024

Abstract excerpt

Granulomas, organized aggregates of immune cells which form in response to Mycobacterium tuberculosis ( Mtb ), are characteristic but not exclusive of tuberculosis (TB). Despite existing investigations on TB granulomas, the determinants that differentiate host-protective granulomas from granulomas that contribute to TB pathogenesis are often disputed. Thus, the goal of this narrative review is to help clarify the...

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PMID: 39717773
DOI: 10.3389/fimmu.2024.1427559

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