Article
Structural deficiencies in granuloma formation in TNF gene-targeted mice underlie the heightened susceptibility to aerosol Mycobacterium tuberculosis infection, which is not compensated for by lymphotoxin.
Journal of immunology (Baltimore, Md. : 1950) - 15 Mar 1999
Bean A G, Roach D R, Briscoe H, France M P, Korner H, Sedgwick J D, Britton W J
Abstract excerpt
TNF and lymphotoxin-alpha (LT alpha) may act at various stages of the host response to Mycobacterium tuberculosis. To dissect the effects of TNF independent of LT alpha, we have used C57BL/6 mice with a disruption of the TNF gene alone (TNF-/-). Twenty-one days following aerosol M. tuberculosis i...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.