Article
Diverse immune environments in human lung tuberculosis granulomas assessed by quantitative multiplexed immunofluorescence.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Dec 2020
Abengozar-Muela Marta, Esparza María Villalba, Garcia-Ros David, Vásquez Cindy Estefanía, Echeveste José I, Idoate Miguel Angel, Lozano Maria D, Melero Ignacio, de Andrea Carlos E
Abstract excerpt
The precise nature of the local immune responses in lung tuberculosis (TB) granulomas requires a comprehensive understanding of their environmental complexities. At its most basic level, a granuloma is a compact, organized immune aggregate of macrophages surrounded by myeloid, B and T cells. We established two complementary multiplex immunolabeling panels to simultaneously evaluate the myeloid and lymphocytic...
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