Individuals with latent tuberculosis infection display pulmonary airway enrichment and recall recruitment of CD4+ TRM with protective functional phenotypes.

Abstract excerpt

Tuberculosis (TB) remains a worldwide public health threat, in part because of the limited efficacy of current BCG vaccination. Respiratory infection with Mycobacterium tuberculosis (Mtb) is most often followed by the development of protective immunity that contains the pathogen, resulting in latent tuberculosis infection (LTBI). We previously introduced bronchoscopic challenge of LTBI individuals using...

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