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<i>Mycobacterium tuberculosis</i> ‐specific CD8 <sup>+</sup> T cells are functionally and phenotypically different between latent infection and active disease

4 Mar 2013

Abstract excerpt

Protective immunity to Mycobacterium tuberculosis (Mtb) remains poorly understood and the role of Mtb-specific CD8(+) T cells is controversial. Here we performed a broad phenotypic and functional characterization of Mtb-specific CD8(+) T cells in 326 subjects with latent Mtb infection (LTBI) or active TB disease (TB). Mtb-specific CD8(+) T cells were detected in most (60%) TB patients and few (15%) LTBI subjects...

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PMID: 23456989
DOI: 10.1002/eji.201243262

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