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The presence of cytotoxic CD4 and exhausted-like CD8+ T-cells is a signature of active tuberculosis

9 May 2024

Abstract excerpt

Chronic infections induce CD4+ T-cells with cytotoxic functions (CD4 CTLs); at present, it is still unknown whether latent tuberculosis (LTB) and active tuberculosis (ATB) induce CD4 CTLs. Plasma and cells from four patient groups-uninfected contact (UC), LTB, and ATB (divided as sensitive [DS-TB]- or resistant [DR-TB]-drug)-were evaluated by flow cytometry, q-PCR, and proteomics. The data showed that ATB...

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Identifiers

PMID: 38734321
DOI: 10.1016/j.bbadis.2024.167219

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