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Article

Mutations of the conserved DRS motif in the second intracellular loop of the gonadotropin-releasing hormone receptor affect expression, activation, and internalization.

Molecular endocrinology (Baltimore, Md.) - 1 Aug 1997

Arora K K, Cheng Z, Catt K J

Abstract excerpt

The GnRH receptor is an unusual member of the G protein-coupled receptor (GPCR) superfamily with several unique features. One of these is a variant of the conserved DRY motif that is located at the junction of the third transmembrane domain and the second intracellular (2i) loop of most GPCRs. In the GnRH receptor, the Tyr residue of the conserved triplet is replaced by Ser, giving a DRS sequence. The aspartate...

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Identifiers

PMID: 9259312
DOI: 10.1210/mend.11.9.9968

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Source receipt: pubmed, retrieved 7 Sept 2026.

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