Article
Mutations of the conserved DRS motif in the second intracellular loop of the gonadotropin-releasing hormone receptor affect expression, activation, and internalization.
Molecular endocrinology (Baltimore, Md.) - 1 Aug 1997
Arora K K, Cheng Z, Catt K J
Abstract excerpt
The GnRH receptor is an unusual member of the G protein-coupled receptor (GPCR) superfamily with several unique features. One of these is a variant of the conserved DRY motif that is located at the junction of the third transmembrane domain and the second intracellular (2i) loop of most GPCRs. In...
Topics
- Amino Acid Sequence
- Animals
- Binding Sites
- COS Cells
- Conserved Sequence
- Gonadotropin-Releasing Hormone
- Guanosine 5'-O-(3-Thiotriphosphate)
- Inositol Phosphates
- Iodine Radioisotopes
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Mutation
- Protein Conformation
- Receptors, LHRH
- Recombinant Proteins
- Signal Transduction