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Article

Functional importance of charged residues within the putative intracellular loops in pH regulation by Na+/ H+ exchanger NHE1.

The FEBS journal - 1 Aug 2007

Hisamitsu Takashi, Yamada Keiji, Nakamura Tomoe Y, Wakabayashi Shigeo

Abstract excerpt

The plasma membrane Na+/H+ exchanger 1 is activated in response to various extrinsic factors, and this process is regulated by an intracellular pH-sensing mechanism. To identify the candidate residues responsible for intracellular pH regulation, we analyzed the functional properties of engineered Na+/H+ exchanger 1 mutants with charge-reversal mutations of charged residues located in the intracellular loops....

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Identifiers

PMID: 17662110
DOI: 10.1111/j.1742-4658.2007.05962.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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