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Article

Acidic residues of extracellular loop 3 of the Na+/H+ exchanger type 1 are important in cation transport.

Molecular and cellular biochemistry - 1 May 2020

Li Xiuju, Quan Sicheng, Corsiatto Thomas, Fliegel Larry

Abstract excerpt

Mammalian Na+/H+ exchanger type I isoform (NHE1) is a ubiquitously expressed membrane protein that regulates intracellular pH (pHi) by removing one intracellular proton in exchange for one extracellular sodium ion. Abnormal activity of the protein occurs in cardiovascular disease and breast cancer. The purpose of this study is to examine the role of negatively charged amino acids of extracellular loop 3 (EL3) in...

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Identifiers

PMID: 32130622
DOI: 10.1007/s11010-020-03707-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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