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Article

Responsiveness of mutants of NHE1 isoform of Na+/H+ antiport to osmotic stress.

The American journal of physiology - 1 Oct 1995

Bianchini L, Kapus A, Lukacs G, Wasan S, Wakabayashi S, Pouysségur J, Yu F H, Orlowski J, Grinstein S

Abstract excerpt

Hypertonic activation of NHE1, the ubiquitous Na+/H+ exchanger, plays a central role in cell volume regulation, yet little is known about the underlying mechanism. We probed the osmotic responsiveness of full-length and truncated constructs of NHE1 transfected into cells lacking endogenous antiport activity. The hypertonic stimulation of NHE1 was preserved after heterologous transfection of the full-length NHE1...

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PMID: 7485471
DOI: 10.1152/ajpcell.1995.269.4.C998

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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