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Article

Diverse residues of intracellular loop 5 of the Na+/H+ exchanger modulate proton sensing, expression, activity and targeting.

Biochimica et biophysica acta. Biomembranes - 1 Jan 2019

Wong Ka Yee, McKay Ryan, Liu Yongsheng, Towle Kaitlyn, Elloumi Yesmine, Li Xiuju, Quan Sicheng, Dutta Debajyoti, Sykes Brian D, Fliegel Larry

Abstract excerpt

The mammalian Na+/H+ exchanger isoform 1 (NHE1) is an integral membrane protein that regulates intracellular pH (pHi) by removing a single intracellular proton in exchange for one extracellular sodium ion. It is involved in cardiac hypertrophy and ischemia reperfusion damage to the heart and elevation of its activity is a trigger for breast cancer metastasis. NHE1 has an extensive 500 amino acid N-terminal...

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Alanine
Cytoplasm
Hydrogen-Ion Concentration
Ion Transport
Magnetic Resonance Spectroscopy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Domains

Sodium-Hydrogen Exchangers

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PMID: 30071192
DOI: 10.1016/j.bbamem.2018.07.014

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Diverse residues of intracellular loop 5 of the Na+/H+ exchanger modulate proton sensing, expression, activity and targeting.PMID 30071192Read ↗

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