Article
p38alpha MAPK can positively or negatively regulate Rac-1 activity depending on the presence of serum.
FEBS letters - 7 Aug 2007
Zuluaga Susana, Gutiérrez-Uzquiza Alvaro, Bragado Paloma, Alvarez-Barrientos Alberto, Benito Manuel, Nebreda Angel R, Porras Almudena
Abstract excerpt
The small GTP-ase Rac-1 can trigger p38 MAPK activation and, in turn, p38alpha can regulate signalling pathways that potentially impinge on Rac-1 activity. We have investigated the cross-talk between p38alpha and Rac-1 and found that p38alpha regulates the association between Rac-1 and caveolin-1 in serum-deprived cardiomyocytes. This interaction depends on cell attachment and correlates with higher levels of...
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