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Article

Adhesion to the extracellular matrix regulates the coupling of the small GTPase Rac to its effector PAK.

The EMBO journal - 2 May 2000

del Pozo M A, Price L S, Alderson N B, Ren X D, Schwartz M A

Abstract excerpt

The small GTPase Rac regulates cytoskeletal organization, cell cycle progression, gene expression and oncogenic transformation, processes that depend upon both soluble growth factors and adhesion to the extracellular matrix (ECM). We now show that growth factors and adhesion to the ECM both contr...

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Identifiers

PMID: 10790367
DOI: 10.1093/emboj/19.9.2008
PMCID: PMC305684

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-10790367-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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