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Article

Epac-Rap1-activated mesenchymal stem cells improve cardiac function in rat model of myocardial infarction.

Cardiovascular therapeutics - 1 Apr 2017

Khan Irfan, Ali Anwar, Akhter Muhammad Aleem, Naeem Nadia, Chotani Maqsood Ahmed, Iqbal Hana'a, Kabir Nurul, Atiq Mehnaz, Salim Asmat

Abstract excerpt

INTRODUCTION: Rap1, a member of Ras superfamily of small GTP-binding proteins, is involved in cardiovascular biology in numerous ways. It is an evolutionary conserved regulator of adhesion, polarity, differentiation and growth. AIMS: Our aim was to analyze Rap1-activated rat bone marrow mesenchymal stem cells (MSCs) for their potential role in adhesion and cardiac differentiation. METHODS: Myocardial infarction...

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PMID: 28039940
DOI: 10.1111/1755-5922.12248

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