Article
R-Ras and Rac GTPase cross-talk regulates hematopoietic progenitor cell migration, homing, and mobilization.
The Journal of biological chemistry - 8 Jul 2011
Shang Xun, Cancelas Jose A, Li Lina, Guo Fukun, Liu Wei, Johnson James F, Ficker Ashley, Daria Deidre, Geiger Hartmut, Ratner Nancy, Zheng Yi
Abstract excerpt
Adult hematopoietic progenitor cells (HPCs) are maintained by highly coordinated signals in the bone marrow. The molecular mechanisms linking intracellular signaling network of HPCs with their microenvironment remain poorly defined. The Rho family GTPase Rac1/Rac2 has previously been implicated in cell functions involved in HPC maintenance, including adhesion, migration, homing, and mobilization. In the present...
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