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Article

β1-Integrin is up-regulated via Rac1-dependent reactive oxygen species as part of the hypertrophic cardiomyocyte response.

Free radical biology & medicine - 1 Aug 2011

Häuselmann Stéphanie P, Rosc-Schlüter Berit I, Lorenz Vera, Plaisance Isabelle, Brink Marijke, Pfister Otmar, Kuster Gabriela M

Abstract excerpt

β(1)-Integrin mediates cardiomyocyte growth and survival and its proper regulation is essential for the structural and functional integrity of the heart. β(1)-Integrin expression is enhanced in hypertrophy, but the mechanism and significance of its up-regulation are unknown. Because reactive oxygen species (ROS) are important mediators of myocardial remodeling we examined their role in regulated β(1)-integrin...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21620958
DOI: 10.1016/j.freeradbiomed.2011.05.007

Genes

EGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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