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Article

F-actin-dependent translocation of the Rap1 GDP/GTP exchange factor RasGRP2.

The Journal of biological chemistry - 7 May 2004

Caloca Mariía J, Zugaza José L, Vicente-Manzanares Miguel, Sánchez-Madrid Francisco, Bustelo Xosé R

Abstract excerpt

RasGRPs constitute a new group of diacylglycerol-dependent GDP/GTP exchange factors that activate Ras subfamily GTPases. Despite a common structure, Ras-GRPs diverge in their GTPase specificity, subcellular distribution, and downstream biological effects. The more divergent family member is RasGRP2, a Rap1-specific exchange factor with low affinity toward diacylglycerol. The regulation of RasGRP2 during signal...

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PMID: 14988412
DOI: 10.1074/jbc.M313013200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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