HDAC4 reduction: a novel therapeutic strategy to target cytoplasmic huntingtin and ameliorate neurodegeneration.

doi:10.1371/journal.pbio.1001717

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Article

HDAC4 reduction: a novel therapeutic strategy to target cytoplasmic huntingtin and ameliorate neurodegeneration.

PLoS biology - 1 Nov 2013

Mielcarek Michal, Landles Christian, Weiss Andreas, Bradaia Amyaouch, Seredenina Tamara, Inuabasi Linda, Osborne Georgina F, Wadel Kristian, Touller Chrystelle, Butler Rachel, Robertson Janette, Franklin Sophie A, Smith Donna L, Park Larry, Marks Paul A, Wanker Erich E, Olson Eric N, Luthi-Carter Ruth, van der Putten Herman, Beaumont Vahri, Bates Gillian P

Abstract excerpt

Histone deacetylase (HDAC) 4 is a transcriptional repressor that contains a glutamine-rich domain. We hypothesised that it may be involved in the molecular pathogenesis of Huntington's disease (HD), a protein-folding neurodegenerative disorder caused by an aggregation-prone polyglutamine expansion in the huntingtin protein. We found that HDAC4 associates with huntingtin in a polyglutamine-length-dependent manner...

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Identifiers

PMID: 24302884
DOI: 10.1371/journal.pbio.1001717
PMCID: PMC3841096

Genes

HDAC4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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