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Article

Histone deacetylases and their role in motor neuron degeneration

1 Jan 2013

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease, characterized by the progressive loss of motor neurons. The cause of this selective neuronal death is unknown, but transcriptional dysregulation is recently emerging as an important factor. The physical substrate for the regulation of the transcriptional process is chromatin, a complex assembly of histones and DNA. Histones are subject to...

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PMID: 24367290
DOI: 10.3389/fncel.2013.00243

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