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Article

The role of LANP and ataxin 1 in E4F-mediated transcriptional repression.

EMBO reports - 1 Jul 2007

Cvetanovic Marija, Rooney Robert J, Garcia Jesus J, Toporovskaya Nataliya, Zoghbi Huda Y, Opal Puneet

Abstract excerpt

The leucine-rich acidic nuclear protein (LANP) belongs to the INHAT family of corepressors that inhibits histone acetyltransferases. The mechanism by which LANP restricts its repression to specific genes is unknown. Here, we report that LANP forms a complex with transcriptional repressor E4F and modulates its activity. As LANP interacts with ataxin 1--a protein mutated in the neurodegenerative disease...

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Identifiers

PMID: 17557114
DOI: 10.1038/sj.embor.7400983
PMCID: PMC1905893

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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