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Article

RNA association and nucleocytoplasmic shuttling by ataxin-1.

Journal of cell science - 1 Jan 2005

Irwin Stuart, Vandelft Mark, Pinchev Deborah, Howell Jenny L, Graczyk Joanna, Orr Harry T, Truant Ray

Abstract excerpt

Spinocerebellar ataxia type 1 (SCA1) is a dominant neurodegenerative disease caused by the expression of mutant ataxin-1 containing an expanded polyglutamine tract. Ataxin-1 is a nuclear protein that localizes to punctate inclusions similar to neuronal nuclear inclusions seen in many polyglutamine expansion disease proteins. We demonstrate that ataxin-1 localization to inclusions and inclusion dynamics within the...

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Source

Identifiers

PMID: 15615787
DOI: 10.1242/jcs.01611

Genes

NXF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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