Article
Ataxin-2 promotes apoptosis of human neuroblastoma cells.
Oncogene - 23 Jan 2003
Wiedemeyer Ruprecht, Westermann Frank, Wittke Isabel, Nowock Joachim, Schwab Manfred
Abstract excerpt
Neuroblastoma is a highly heterogeneous tumor of young children. Although many advances have been made towards understanding the molecular mechanisms dictating the phenotypic heterogeneity, the prognosis of children with neuroblastoma, particularly of progressively growing variants, has remained dire. About 10% of neuroblastomas regress spontaneously, probably by apoptosis, while another 20% have amplified the...
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