Article
The deacetylase HDAC4 controls myocyte enhancing factor-2-dependent structural gene expression in response to neural activity.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jan 2009
Cohen Todd J, Barrientos Tomasa, Hartman Zachary C, Garvey Sean M, Cox Gregory A, Yao Tso-Pang
Abstract excerpt
Histone deacetylase 4 (HDAC4) binds and inhibits activation of the critical muscle transcription factor myocyte enhancer factor-2 (MEF2). However, the physiological significance of the HDAC4-MEF2 complex in skeletal muscle has not been established. Here we show that in skeletal muscle, HDAC4 is a critical modulator of MEF2-dependent structural and contractile gene expression in response to neural activity. We...
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