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Article

TDP-43 knockdown impairs neurite outgrowth dependent on its target histone deacetylase 6

1 Jan 2011

Abstract excerpt

BACKGROUND: Trans-activation response element (TAR) DNA binding protein of 43kDa (TDP-43) is causally related to the neurodegenerative diseases frontotemporal dementia and amyotrophic lateral sclerosis being the hallmark protein in the disease-characteristic neuropathological lesions and via genetic linkage. Histone deacetylase 6 (HDAC6) is an established target of the RNA-binding protein TDP-43. HDAC6 is an...

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PMID: 21878116
DOI: 10.1186/1750-1326-6-64

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