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Article

Human carboxylesterase 1A2 expressed from carboxylesterase 1A1 and 1A2 genes is a potent predictor of CPT-11 cytotoxicity in vitro.

Pharmacogenetics and genomics - 1 Jan 2007

Tanimoto Keiji, Kaneyasu Mika, Shimokuni Tatsushi, Hiyama Keiko, Nishiyama Masahiko

Abstract excerpt

BACKGROUND: The conversion of CPT-11 to its active form, SN-38, by carboxylesterases (CESs) is a critical event in CPT-11-induced cytotoxicity. Among the CESs, CES1 and CES2 probably play a major role in the metabolism, but the functional significance and molecular basis of CES1 on CPT-11 response remain unclear. METHODS AND RESULTS: We investigated CES1A1 (AB119997) and CES1A2 (AB187225), whose coding sequences...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17264798
DOI: 10.1097/01.fpc.0000230110.18957.50

Genes

CES1
CES2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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