Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Interaction of P53 Arg72Pro and MDM2 T309G polymorphisms and their associations with risk of gastric cardia cancer.

Carcinogenesis - 1 Sept 2007

Yang Ming, Guo Yongli, Zhang Xuemei, Miao Xiaoping, Tan Wen, Sun Tong, Zhao Dan, Yu Dianke, Liu Junniao, Lin Dongxin

Abstract excerpt

The P53 tumor suppressor pathway plays an important role in cancer development. The auto-regulatory feedback mechanism of the P53 and MDM2 expression is critical in keeping proper tumor suppressor function of this pathway. This study examined the effect of P53 Arg72Pro variants on transactivation of polymorphic MDM2 promoter (T309G) and their associations with risk of developing gastric cardia adenocarcinoma...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arginine
Share to Genes, Reporter

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Guanine

Share to Proline

Share to Proto-Oncogene Proteins c-mdm2

Share to Stomach Neoplasms

Share to Thymine

Share to Transcriptional Activation

Source

Identifiers

PMID: 17638920
DOI: 10.1093/carcin/bgm168

Genes

MDM2
GCA

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Interaction of P53 Arg72Pro and MDM2 T309G polymorphisms and their associations with risk of gastric cardia cancer.PMID 17638920Read ↗

Effects of p53 codon 72 and MDM2 SNP309 polymorphisms on gastric cancer risk among the Iranian population.Semantic proximity Read ↗

MDM2 SNP309, gene-gene interaction, and tumor susceptibility: an updated meta-analysis.Semantic proximity Read ↗

Association between MDM2 SNP309 T>G and risk of gastric cancer: a meta-analysis.Semantic proximity Read ↗

Polymorphisms of p53 codon 72 and MDM2 promoter 309 and the risk of endometrial cancer.Semantic proximity Read ↗

Involvement of p53 R72P polymorphism in the association of MDM2-SNP309 with breast cancer.Semantic proximity Read ↗

MDM2 SNP309 rs2279744 polymorphism and gastric cancer risk: a meta-analysis.Semantic proximity Read ↗

Interaction between p53 codon 72 and MDM2 309T>G polymorphisms and the risk of hepatocellular carcinoma.Semantic proximity Read ↗

Association between MDM2 SNP309, p53 Arg72Pro, and hepatocellular carcinoma risk: A MOOSE-compliant meta-analysis.Semantic proximity Read ↗

TP53 and MDM2 gene polymorphisms, gene-gene interaction, and hepatocellular carcinoma risk: evidence from an updated meta-analysis.Semantic proximity Read ↗

Meta-analysis of the MDM2 T309G polymorphism and gastric cancer risk.Semantic proximity Read ↗

Current evidence on the relationship between SNP309 polymorphism in the MDM2 gene and colorectal cancer risk.Semantic proximity Read ↗

Association of polymorphism in MDM-2 and p53 genes with breast cancer risk in Indian women.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.