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Article

Interaction between p53 codon 72 and MDM2 309T>G polymorphisms and the risk of hepatocellular carcinoma.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Mar 2016

Qiu Moqin, Liu Yingchun, Yu Xiangyuan, Qin Linyuan, Bei Chunhua, Zeng Xiaoyun, Qiu Xiaoqiang, Tang Bo, He Songqing, Yu Hongping

Abstract excerpt

The p53 tumor suppressor and its negative regulator, murine double minute 2 (MDM2), play critical roles in carcinogenesis. P53 codon 72 and MDM2 309T>G polymorphisms could influence p53 and MDM2 function, respectively, and might affect cancer susceptibility. We therefore investigated the association between these two SNPs, alone or in combination, and the risk of hepatocellular carcinoma (HCC) in Chinese. In this...

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Share to Linkage Disequilibrium
Share to Carcinoma, Hepatocellular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Liver Neoplasms

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Share to Proto-Oncogene Proteins c-mdm2

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Source

Identifiers

PMID: 26476535
DOI: 10.1007/s13277-015-4222-4

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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