The role of two surface exposed loops in transcription activation by the Escherichia coli CRP and FNR proteins.

doi:10.1093/nar/19.24.6705

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Article

The role of two surface exposed loops in transcription activation by the Escherichia coli CRP and FNR proteins.

Nucleic acids research - 25 Dec 1991

Williams R, Bell A, Sims G, Busby S

Abstract excerpt

We have investigated a number of mutations that alter the ability of the E. coli transcription factors CRP and FNR to activate transcription. In CRP, some mutations at position 159 (H159L, H159I and delta 159) prevent transcription activation at a number of naturally-occurring and semi-synthetic CRP-dependent promoters. We suggest that some feature of the surface-exposed turn around residue 159 is recognised by...

Topics

Amino Acid Sequence
Bacterial Proteins
Base Sequence
Carrier Proteins
Cyclic AMP Receptor Protein
Escherichia coli
Escherichia coli Proteins
Iron-Sulfur Proteins
Macromolecular Substances
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Nucleic Acid Conformation

Promoter Regions, Genetic

Receptors, Cyclic AMP

Repetitive Sequences, Nucleic Acid

Transcription, Genetic

beta-Galactosidase

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Identifiers

PMID: 1762901
DOI: 10.1093/nar/19.24.6705
PMCID: PMC329298

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1762901-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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