Article
Dissection of a surface-exposed portion of the cAMP-CRP complex that mediates transcription activation and repression.
Molecular microbiology - 1 May 1999
Meibom K L, Søgaard-Andersen L, Mironov A S, Valentin-Hansen P
Abstract excerpt
The Escherichia coli cAMP receptor protein (CRP) is essential for the activation and repression of transcription initiation at promoters in the CytR regulon. CRP performs these activities by making direct protein-protein interactions to the alpha-subunits of RNA polymerase and to the CytR regulator. Strikingly, it has been shown that amino acids of CRP that are critical for communication with the two partner...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.